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| U | Universidad de Chile | - | Cobreloa | 2:1 (1:0) | ||
| R | Cobreloa | - | Universidad de Chile | 2:3 (0:0) | ||
| U: 07.07.2018 23:30 | R: 14.07.2018 21:30 | Winnaars: Universidad de Chile | ||||
| U | Deportes Valdivia | - | Barnechea | 0:1 (0:0) | ||
| R | Barnechea | - | Deportes Valdivia | 5:4 (0:0, 1:2) d.p. | ||
| U: 08.07.2018 18:30 | R: 14.07.2018 02:00 | Winnaars: Barnechea | ||||
| U | Cobresal | - | Palestino | 1:1 (1:1) | ||
| R | Palestino | - | Cobresal | 1:0 (0:0) | ||
| U: 08.07.2018 21:30 | R: 15.07.2018 00:00 | Winnaars: Palestino | ||||
| U | Audax Italiano | - | Huachipato | 2:1 (2:1) | ||
| R | Huachipato | - | Audax Italiano | 1:2 (0:0) | ||
| U: 09.07.2018 00:00 | R: 14.07.2018 18:30 | Winnaars: Audax Italiano | ||||
