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| U | Sporting San Miguelito | - | Tauro FC | 0:1 (0:0) | ||
| R | Tauro FC | - | Sporting San Miguelito | 1:1 (0:1) | ||
| U: 17.08.2022 00:00 | R: 24.08.2022 00:00 | Winnaars: Tauro FC | ||||
| U | Comunicaciones | - | Diriangén FC | 0:1 (0:1) | ||
| R | Diriangén FC | - | Comunicaciones | 1:1 (1:0) | ||
| U: 17.08.2022 02:00 | R: 24.08.2022 04:30 | Winnaars: Diriangén FC | ||||
| U | Pacific FC | - | CS Herediano | 0:1 (0:0) | ||
| R | CS Herediano | - | Pacific FC | 6:5 (0:0, 0:1) d.p. | ||
| U: 17.08.2022 04:00 | R: 24.08.2022 02:15 | Winnaars: CS Herediano | ||||
| U | Cibao FC | - | Motagua | 0:1 (0:0) | ||
| R | Motagua | - | Cibao FC | 2:0 (0:0) | ||
| U: 18.08.2022 02:00 | R: 25.08.2022 02:00 | Winnaars: Motagua | ||||
| U | Hankook Verdes | - | Alianza | 0:2 (0:0) | ||
| R | Alianza | - | Hankook Verdes | 5:1 (2:0) | ||
| U: 18.08.2022 04:00 | R: 25.08.2022 04:15 | Winnaars: Alianza | ||||
| U | Real España | - | CS Cartaginés | 2:0 (1:0) | ||
| R | CS Cartaginés | - | Real España | 0:2 (0:2) | ||
| U: 19.08.2022 00:00 | R: 26.08.2022 00:00 | Winnaars: Real España | ||||
| U | LD Alajuelense | - | Alianza | 5:0 (4:0) | ||
| R | Alianza | - | LD Alajuelense | 1:1 (0:1) | ||
| U: 19.08.2022 02:00 | R: 26.08.2022 02:15 | Winnaars: LD Alajuelense | ||||
| U | CSD Municipal | - | Olimpia | 2:2 (0:2) | ||
| R | Olimpia | - | CSD Municipal | 1:0 (0:0) | ||
| U: 19.08.2022 04:00 | R: 26.08.2022 04:30 | Winnaars: Olimpia | ||||
