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| 27.11.2021 | 10:15 | FK Dukla Praha | - | FK Fotbal Třinec | 0:0 (0:0) | |
| 13:30 | FK MAS Táborsko | - | 1. FK Příbram | 2:3 (1:1) | ||
| 28.11.2021 | 10:15 | Viktoria Žižkov | - | FK Varnsdorf | 0:2 (0:1) | |
| 04.12.2021 | 13:30 | 1. SK Prostějov | - | Sparta Praag B | 1:0 (0:0) | |
| 13:30 | SFC Opava | - | Zbrojovka Brno | 0:2 (0:0) | ||
| 26.02.2022 | 13:30 | MFK Chrudim | - | FC Sellier & Bellot Vlašim | 4:2 (3:0) | |
| 08.03.2022 | 14:00 | SK Líšeň | - | MFK Vyškov | 2:0 (1:0) | |
| 16.03.2022 | 18:00 | Vysočina Jihlava | - | FK Ústí nad Labem | 2:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zbrojovka Brno | 16 | 12 | 2 | 2 | 32:15 | 17 | 38 |
| 2 |
|
SK Líšeň | 16 | 9 | 4 | 3 | 27:15 | 12 | 31 |
| 3 |
|
Sparta Praag B | 16 | 9 | 1 | 6 | 30:19 | 11 | 28 |
| 4 |
|
FC Sellier & Bellot Vlašim | 16 | 8 | 2 | 6 | 33:23 | 10 | 26 |
| 5 |
|
1. SK Prostějov | 16 | 8 | 2 | 6 | 17:20 | -3 | 26 |
| 6 |
|
SFC Opava | 16 | 7 | 4 | 5 | 24:17 | 7 | 25 |
| 7 |
|
FK Varnsdorf | 16 | 7 | 4 | 5 | 28:23 | 5 | 25 |
| 8 |
|
FK Dukla Praha | 16 | 7 | 3 | 6 | 21:21 | 0 | 24 |
| 9 |
|
Vysočina Jihlava | 16 | 6 | 5 | 5 | 15:17 | -2 | 23 |
| 10 |
|
FK MAS Táborsko | 16 | 6 | 4 | 6 | 18:19 | -1 | 22 |
| 11 |
|
FK Ústí nad Labem | 16 | 4 | 6 | 6 | 16:22 | -6 | 18 |
| 12 |
|
MFK Vyškov | 16 | 5 | 2 | 9 | 26:27 | -1 | 17 |
| 13 |
|
1. FK Příbram | 16 | 4 | 5 | 7 | 21:29 | -8 | 17 |
| 14 |
|
FK Fotbal Třinec | 16 | 4 | 2 | 10 | 14:30 | -16 | 14 |
| 15 |
|
MFK Chrudim | 16 | 3 | 4 | 9 | 17:28 | -11 | 13 |
| 16 |
|
Viktoria Žižkov | 16 | 2 | 4 | 10 | 13:27 | -14 | 10 |
| Promotie | |
| Play-offs | |
| Degradatie |
