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| 16.04.2022 | 17:00 | FK Ústí nad Labem | - | MFK Vyškov | 1:1 (0:0) | |
| 17:00 | 1. FK Příbram | - | FC Sellier & Bellot Vlašim | 2:1 (1:1) | ||
| 17:00 | SK Líšeň | - | SFC Opava | 1:1 (1:0) | ||
| 17:00 | 1. SK Prostějov | - | FK Dukla Praha | 2:1 (2:1) | ||
| 17.04.2022 | 10:15 | Viktoria Žižkov | - | FK Fotbal Třinec | 2:2 (1:1) | |
| 10:30 | Sparta Praag B | - | Zbrojovka Brno | 1:0 (0:0) | ||
| 15:00 | FK MAS Táborsko | - | Vysočina Jihlava | 1:1 (0:1) | ||
| 17:00 | FK Varnsdorf | - | MFK Chrudim | 1:2 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zbrojovka Brno | 24 | 18 | 2 | 4 | 48:21 | 27 | 56 |
| 2 |
|
FC Sellier & Bellot Vlašim | 24 | 13 | 3 | 8 | 48:33 | 15 | 42 |
| 3 |
|
Sparta Praag B | 24 | 13 | 3 | 8 | 42:27 | 15 | 42 |
| 4 |
|
SK Líšeň | 24 | 11 | 7 | 6 | 38:27 | 11 | 40 |
| 5 |
|
SFC Opava | 24 | 11 | 7 | 6 | 36:25 | 11 | 40 |
| 6 |
|
FK Varnsdorf | 24 | 10 | 5 | 9 | 39:31 | 8 | 35 |
| 7 |
|
FK Dukla Praha | 24 | 10 | 5 | 9 | 34:33 | 1 | 35 |
| 8 |
|
1. SK Prostějov | 24 | 10 | 3 | 11 | 26:38 | -12 | 33 |
| 9 |
|
Vysočina Jihlava | 24 | 8 | 7 | 9 | 20:27 | -7 | 31 |
| 10 |
|
1. FK Příbram | 24 | 8 | 6 | 10 | 31:39 | -8 | 30 |
| 11 |
|
MFK Vyškov | 24 | 8 | 5 | 11 | 39:38 | 1 | 29 |
| 12 |
|
FK MAS Táborsko | 24 | 7 | 8 | 9 | 25:29 | -4 | 29 |
| 13 |
|
MFK Chrudim | 24 | 7 | 7 | 10 | 24:32 | -8 | 28 |
| 14 |
|
FK Fotbal Třinec | 24 | 7 | 5 | 12 | 26:40 | -14 | 26 |
| 15 |
|
FK Ústí nad Labem | 24 | 5 | 9 | 10 | 22:35 | -13 | 24 |
| 16 |
|
Viktoria Žižkov | 24 | 2 | 6 | 16 | 20:43 | -23 | 12 |
| Promotie | |
| Play-offs | |
| Degradatie |
