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| 25.09.2021 | 15:00 | Stade Brestois | - | FC Lorient | 4:0 (2:0) | |
| 15:00 | Stade Rennais | - | USSA Vertou | 4:1 (0:0) | ||
| 16:00 | CPBB Rennes | - | FC Nantes | 2:5 (2:4) | ||
| 26.09.2021 | 11:00 | EA Guingamp | - | LB Châteauroux | 0:0 (0:0) | |
| 11:00 | Angoulême CFC | - | Vannes OC | 1:2 (0:2) | ||
| 15:00 | La Roche VF | - | Angers SCO | 0:2 (0:2) | ||
| 15:00 | Chamois Niortais | - | SO Cholet | 3:2 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Nantes | 5 | 4 | 1 | 0 | 20:5 | 15 | 13 |
| 2 |
|
Angers SCO | 5 | 4 | 0 | 1 | 15:4 | 11 | 12 |
| 3 |
|
Chamois Niortais | 5 | 3 | 1 | 1 | 11:12 | -1 | 10 |
| 4 |
|
SO Cholet | 5 | 2 | 2 | 1 | 16:13 | 3 | 8 |
| 5 |
|
Vannes OC | 5 | 2 | 2 | 1 | 8:9 | -1 | 8 |
| 6 |
|
Stade Brestois | 5 | 2 | 1 | 2 | 12:8 | 4 | 7 |
| 7 |
|
La Roche VF | 5 | 2 | 1 | 2 | 7:9 | -2 | 7 |
| 8 |
|
EA Guingamp | 5 | 2 | 1 | 2 | 9:12 | -3 | 7 |
| 9 |
|
Stade Rennais | 5 | 1 | 3 | 1 | 12:11 | 1 | 6 |
| 10 |
|
FC Lorient | 5 | 1 | 2 | 2 | 8:11 | -3 | 5 |
| 11 |
|
USSA Vertou | 5 | 1 | 2 | 2 | 5:9 | -4 | 5 |
| 12 |
|
Angoulême CFC | 5 | 1 | 1 | 3 | 5:10 | -5 | 4 |
| 13 |
|
LB Châteauroux | 5 | 0 | 2 | 3 | 3:10 | -7 | 2 |
| 14 |
|
CPBB Rennes | 5 | 0 | 1 | 4 | 4:12 | -8 | 1 |
| Degradatie |
