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| 23.10.2021 | 18:00 | Andrézieux-Bouthéon FC | - | Trélissac FC | 0:1 (0:0) | |
| 18:00 | Bergerac Périgord FC | - | Le Puy Foot 43 | 2:2 (0:1) | ||
| 18:00 | FC Nantes B | - | Canet Roussillon | 1:2 (0:0) | ||
| 18:00 | Montpellier HSC B | - | AS Béziers | 2:0 (1:0) | ||
| 18:00 | Angers SCO B | - | Bourges Foot 18 | 0:3 (0:2) | ||
| 18:00 | US Colomiers | - | Angoulême CFC | 3:3 (0:0) | ||
| 18:00 | Vendée Les Herbiers | - | Stade Montois | 1:0 (1:0) | ||
| 20:00 | FC Chamalières | - | Moulins Yzeure Foot | 3:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Angoulême CFC | 10 | 6 | 2 | 2 | 17:11 | 6 | 20 |
| 2 |
|
Bergerac Périgord FC | 10 | 5 | 3 | 2 | 14:8 | 6 | 18 |
| 3 |
|
Andrézieux-Bouthéon FC | 10 | 5 | 1 | 4 | 13:9 | 4 | 16 |
| 4 |
|
FC Nantes B | 10 | 4 | 4 | 2 | 13:10 | 3 | 16 |
| 5 |
|
Moulins Yzeure Foot | 10 | 4 | 4 | 2 | 8:6 | 2 | 16 |
| 6 |
|
Trélissac FC | 10 | 5 | 1 | 4 | 10:10 | 0 | 16 |
| 7 |
|
Le Puy Foot 43 | 10 | 4 | 3 | 3 | 12:8 | 4 | 15 |
| 8 |
|
AS Béziers | 10 | 4 | 3 | 3 | 9:10 | -1 | 15 |
| 9 |
|
Bourges Foot 18 | 10 | 4 | 2 | 4 | 11:7 | 4 | 14 |
| 10 |
|
Vendée Les Herbiers | 10 | 3 | 4 | 3 | 12:13 | -1 | 13 |
| 11 |
|
US Colomiers | 10 | 3 | 3 | 4 | 10:11 | -1 | 12 |
| 12 |
|
Angers SCO B | 10 | 3 | 3 | 4 | 10:12 | -2 | 12 |
| 13 |
|
Canet Roussillon | 10 | 6 | 3 | 1 | 13:8 | 5 | 10 |
| 14 |
|
Montpellier HSC B | 10 | 2 | 2 | 6 | 10:13 | -3 | 8 |
| 15 |
|
FC Chamalières | 10 | 2 | 2 | 6 | 11:17 | -6 | 8 |
| 16 |
|
Stade Montois | 10 | 0 | 0 | 10 | 7:27 | -20 | 0 |
| Promotie | |
| Degradatie |
