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| 08.04.2022 | 19:30 | Moulins Yzeure Foot | - | FC Chamalières | 0:0 (0:0) | |
| 09.04.2022 | 18:00 | Angoulême CFC | - | US Colomiers | 0:2 (0:1) | |
| 18:00 | AS Béziers | - | Montpellier HSC (CFA) | 2:2 (2:2) | ||
| 18:00 | Bourges Foot 18 | - | Angers SCO II | 0:1 (0:1) | ||
| 18:00 | Canet Roussillon | - | FC Nantes (CFA) | 1:0 (0:0) | ||
| 18:00 | Le Puy Foot 43 | - | Bergerac Foot | 1:0 (0:0) | ||
| 18:00 | Trélissac FC | - | Andrézieux-Bouthéon FC | 0:1 (0:0) | ||
| 18:30 | Stade Montois | - | Vendée Les Herbiers | 1:2 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bergerac Foot | 24 | 13 | 8 | 3 | 28:12 | 16 | 47 |
| 2 |
|
Andrézieux-Bouthéon FC | 24 | 13 | 5 | 6 | 33:20 | 13 | 44 |
| 3 |
|
Le Puy Foot 43 | 24 | 12 | 7 | 5 | 30:15 | 15 | 43 |
| 4 |
|
Angoulême CFC | 24 | 12 | 7 | 5 | 29:18 | 11 | 43 |
| 5 |
|
Bourges Foot 18 | 24 | 11 | 5 | 8 | 33:22 | 11 | 38 |
| 6 |
|
Moulins Yzeure Foot | 24 | 8 | 10 | 6 | 24:22 | 2 | 34 |
| 7 |
|
Vendée Les Herbiers | 24 | 9 | 7 | 8 | 28:28 | 0 | 34 |
| 8 |
|
AS Béziers | 24 | 8 | 8 | 8 | 29:27 | 2 | 32 |
| 9 |
|
FC Nantes (CFA) | 24 | 8 | 8 | 8 | 28:27 | 1 | 32 |
| 10 |
|
Angers SCO II | 24 | 6 | 11 | 7 | 23:23 | 0 | 29 |
| 11 |
|
Trélissac FC | 24 | 7 | 6 | 11 | 21:23 | -2 | 27 |
| 12 |
|
Canet Roussillon | 24 | 11 | 5 | 8 | 22:27 | -5 | 27 |
| 13 |
|
FC Chamalières | 24 | 7 | 6 | 11 | 26:32 | -6 | 27 |
| 14 |
|
Montpellier HSC (CFA) | 24 | 6 | 6 | 12 | 25:36 | -11 | 24 |
| 15 |
|
US Colomiers | 24 | 5 | 8 | 11 | 24:33 | -9 | 23 |
| 16 |
|
Stade Montois | 24 | 1 | 3 | 20 | 15:53 | -38 | 6 |
| Promotie | |
| Degradatie |
