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| U | Fostiras FC | - | Panionios GSS | 1:0 (1:0) | ||
| R | Panionios GSS | - | Fostiras FC | 2:1 (2:0) | ||
| U: 28.11.2012 13:30 | R: 19.12.2012 19:00 | Winnaars: Fostiras FC | ||||
| U | Levadiakos | - | Pierikos Katerini | 2:0 (1:0) | ||
| R | Pierikos Katerini | - | Levadiakos | 0:5 (0:2) | ||
| U: 28.11.2012 17:30 | R: 20.12.2012 19:00 | Winnaars: Levadiakos | ||||
| U | OFI Heraklion | - | Apollon Smyrnis | 1:0 (0:0) | ||
| R | Apollon Smyrnis | - | OFI Heraklion | 2:0 (1:0, 1:0) n.v. | ||
| U: 28.11.2012 17:30 | R: 22.12.2012 16:00 | Winnaars: Apollon Smyrnis | ||||
| U | Olympiakos | - | Panachaiki GE | 2:0 (0:0) | ||
| R | Panachaiki GE | - | Olympiakos | 0:3 Toeg. | ||
| U: 28.11.2012 19:30 | R: 19.12.2012 19:00 | Winnaars: Olympiakos | ||||
| U | Tyrnavos FC | - | AO Kerkyra | 0:2 (0:1) | ||
| R | AO Kerkyra | - | Tyrnavos FC | 0:0 (0:0) | ||
| U: 29.11.2012 13:30 | R: 20.12.2012 16:00 | Winnaars: AO Kerkyra | ||||
| U | Panthrakikos | - | Niki Volou FC | 2:0 (1:0) | ||
| R | Niki Volou FC | - | Panthrakikos | 1:1 (0:0) | ||
| U: 29.11.2012 17:30 | R: 19.12.2012 16:00 | Winnaars: Panthrakikos | ||||
| U | Panathinaikos | - | AO Proodeftiki | 4:0 (2:0) | ||
| R | AO Proodeftiki | - | Panathinaikos | 1:2 (1:0) | ||
| U: 29.11.2012 17:30 | R: 19.12.2012 13:00 | Winnaars: Panathinaikos | ||||
| U | PAS Giannina | - | Panserraikos | 1:0 (1:0) | ||
| R | Panserraikos | - | PAS Giannina | 0:2 (0:1) | ||
| U: 29.11.2012 19:30 | R: 23.12.2012 19:00 | Winnaars: PAS Giannina | ||||
| U | Veria FC | - | Thrasyvoulos Fylis | 0:0 (0:0) | ||
| R | Thrasyvoulos Fylis | - | Veria FC | 0:2 (0:1) | ||
| U: 12.12.2012 17:30 | R: 20.12.2012 16:00 | Winnaars: Veria FC | ||||
| U | GS Kallithea | - | Aris Saloniki | 3:1 (1:0) | ||
| R | Aris Saloniki | - | GS Kallithea | 2:1 (1:0) | ||
| U: 12.12.2012 17:30 | R: 23.12.2012 19:00 | Winnaars: GS Kallithea | ||||
| U | Olympiakos Volou | - | Atromitos | 1:1 (1:0) | ||
| R | Atromitos | - | Olympiakos Volou | 2:2 (1:0) | ||
| U: 12.12.2012 19:30 | R: 22.12.2012 19:00 | Winnaars: Olympiakos Volou | ||||
| U | AE Lárissa | - | Asteras Tripolis | 0:0 (0:0) | ||
| R | Asteras Tripolis | - | AE Lárissa | 4:1 (2:0) | ||
| U: 12.12.2012 19:30 | R: 22.12.2012 16:00 | Winnaars: Asteras Tripolis | ||||
| U | Platanias Chanion | - | Anagennisi Karditsa | 3:1 (2:1) | ||
| R | Anagennisi Karditsa | - | Platanias Chanion | 0:1 (0:1) | ||
| U: 13.12.2012 15:30 | R: 23.12.2012 16:00 | Winnaars: Platanias Chanion | ||||
| U | AO Kavala | - | AEK Athene | 0:0 (0:0) | ||
| R | AEK Athene | - | AO Kavala | 0:1 (0:0) | ||
| U: 13.12.2012 17:30 | R: 20.12.2012 19:00 | Winnaars: AO Kavala | ||||
| U | Ethnikos Gazoros | - | Skoda Xanthi | 1:1 (0:0) | ||
| R | Skoda Xanthi | - | Ethnikos Gazoros | 5:4 (0:1, 1:1, 1:1) d.p. | ||
| U: 13.12.2012 19:30 | R: 23.12.2012 16:00 | Winnaars: Skoda Xanthi | ||||
| U | Aiginiakos FC | - | PAOK Saloniki | 1:3 (1:2) | ||
| R | PAOK Saloniki | - | Aiginiakos FC | 2:1 (1:0) | ||
| U: 13.12.2012 19:30 | R: 22.12.2012 19:00 | Winnaars: PAOK Saloniki | ||||
