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| 13.04.2022 | 13:00 | Asteras Vlachioti | - | OFI Ierapetra | 4:1 (2:1) | |
| 14:00 | Diagoras FC | - | APS Zakynthos | 2:0 (1:0) | ||
| 14:00 | AE Karaiskakis | - | AO Egaleo | 3:1 (1:0) | ||
| 14:00 | Panathinaikos II | - | Irodotos | 1:2 (0:2) | ||
| 14:00 | AEK Athen II | - | AS Rhodos | 5:0 (3:0) | ||
| 14:00 | AE Kifisias | - | AO Episkopi | 0:1 (0:0) | ||
| 14:30 | Kalamata | - | Levadiakos | 1:0 (0:0) | ||
| 17:00 | Ergotelis | - | GS Kallithea | 0:2 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Levadiakos | 29 | 19 | 6 | 4 | 61:19 | 42 | 63 |
| 2 |
|
GS Kallithea | 29 | 17 | 7 | 5 | 38:17 | 21 | 58 |
| 3 |
|
PAE Chania | 29 | 13 | 13 | 3 | 42:19 | 23 | 52 |
| 4 |
|
Kalamata | 29 | 16 | 7 | 6 | 41:19 | 22 | 52 |
| 5 |
|
AE Kifisias | 30 | 15 | 4 | 11 | 34:27 | 7 | 49 |
| 6 |
|
AEK Athen II | 30 | 13 | 9 | 8 | 33:24 | 9 | 48 |
| 7 |
|
AO Episkopi | 29 | 12 | 9 | 8 | 23:15 | 8 | 45 |
| 8 |
|
AO Egaleo | 29 | 12 | 7 | 10 | 27:27 | 0 | 43 |
| 9 |
|
Ergotelis | 29 | 11 | 7 | 11 | 23:28 | -5 | 40 |
| 10 |
|
OFI Ierapetra | 29 | 9 | 6 | 14 | 36:44 | -8 | 33 |
| 11 |
|
Asteras Vlachioti | 29 | 8 | 8 | 13 | 28:30 | -2 | 32 |
| 12 |
|
Panathinaikos II | 29 | 8 | 7 | 14 | 25:34 | -9 | 31 |
| 13 |
|
Diagoras FC | 29 | 8 | 7 | 14 | 18:33 | -15 | 31 |
| 14 |
|
Irodotos | 29 | 8 | 6 | 15 | 26:41 | -15 | 30 |
| 15 |
|
AE Karaiskakis | 29 | 7 | 7 | 15 | 24:44 | -20 | 28 |
| 16 |
|
AS Rhodos | 29 | 7 | 6 | 16 | 24:42 | -18 | 12 |
| 17 |
|
APS Zakynthos | 30 | 4 | 6 | 20 | 15:55 | -40 | 9 |
| Play-offs | |
| Degradatie | |
| Degradatie |
