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| U | Sanarate | - | Deportivo Guastatoya | 2:0 (2:0) | ||
| R | Deportivo Guastatoya | - | Sanarate | 4:1 (0:0) | ||
| U: 05.05.2021 21:00 | R: 08.05.2021 23:00 | Winnaars: Deportivo Guastatoya | ||||
| U | Sacachispas | - | Comunicaciones | 0:1 (0:1) | ||
| R | Comunicaciones | - | Sacachispas | 1:0 (0:0) | ||
| U: 06.05.2021 03:00 | R: 09.05.2021 02:00 | Winnaars: Comunicaciones | ||||
| U | Iztapa | - | CSD Municipal | 3:1 (1:0) | ||
| R | CSD Municipal | - | Iztapa | 0:0 (0:0) | ||
| U: 06.05.2021 20:00 | R: 09.05.2021 19:00 | Winnaars: Iztapa | ||||
| U | Cobán Imperial | - | Santa Lucía | 1:1 (1:0) | ||
| R | Santa Lucía | - | Cobán Imperial | 3:0 (2:0) | ||
| U: 06.05.2021 23:30 | R: 09.05.2021 22:00 | Winnaars: Santa Lucía | ||||
