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| U | Atlas Guadalajara | - | Deportivo Guadalajara | 0:0 (0:0) | ||
| R | Deportivo Guadalajara | - | Atlas Guadalajara | 2:1 (0:0) | ||
| U: 15.05.2021 00:00 | R: 18.05.2021 04:00 | Winnaars: Deportivo Guadalajara | ||||
| U | CF Monterrey | - | UANL Tigres | 2:2 (0:0) | ||
| R | UANL Tigres | - | CF Monterrey | 4:1 (2:1) | ||
| U: 15.05.2021 04:05 | R: 18.05.2021 02:00 | Winnaars: UANL Tigres | ||||
