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| U | Atlas Guadalajara | - | CF Monterrey | 1:0 (0:0) | ||
| R | CF Monterrey | - | Atlas Guadalajara | 2:1 (0:1) | ||
| U: 10.12.2021 18:00 | R: 14.12.2021 04:00 | Winnaars: Atlas Guadalajara | ||||
| U | CF América | - | UANL Tigres | 2:1 (0:0) | ||
| R | UANL Tigres | - | CF América | 4:0 (0:0) | ||
| U: 11.12.2021 03:00 | R: 14.12.2021 02:00 | Winnaars: UANL Tigres | ||||
