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| U | Atlas Guadalajara | - | UANL Tigres | 0:7 (0:4) | ||
| R | UANL Tigres | - | Atlas Guadalajara | 2:1 (2:1) | ||
| U: 06.05.2022 00:00 | R: 09.05.2022 04:00 | Winnaars: UANL Tigres | ||||
| U | CF Pachuca | - | CF América | 2:1 (1:1) | ||
| R | CF América | - | CF Pachuca | 1:2 (0:1) | ||
| U: 06.05.2022 02:00 | R: 08.05.2022 19:00 | Winnaars: CF Pachuca | ||||
| U | Pumas UNAM | - | Deportivo Guadalajara | 2:2 (0:1) | ||
| R | Deportivo Guadalajara | - | Pumas UNAM | 3:2 (1:2) | ||
| U: 07.05.2022 01:00 | R: 10.05.2022 02:00 | Winnaars: Deportivo Guadalajara | ||||
| U | Club Tijuana | - | CF Monterrey | 0:1 (0:0) | ||
| R | CF Monterrey | - | Club Tijuana | 2:1 (2:0) | ||
| U: 07.05.2022 04:00 | R: 10.05.2022 04:00 | Winnaars: CF Monterrey | ||||
