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| 06.09.2022 | 21:00 | Sportivo Iteño | - | Tacuary | 2:4 | |
| 23:30 | Resistencia SC | - | Atlético Tembetary | 0:1 | ||
| 07.09.2022 | 02:00 | Guaireña FC | - | General Caballero ZC | 5:0 | |
| 21:00 | General Caballero DJLM | - | Guaraní | 1:3 | ||
| 23:30 | Sol de América | - | Club Nacional | 0:3 | ||
| 08.09.2022 | 02:00 | Club Olimpia | - | Libertad | 0:4 | |
| 22:00 | Club Rubio Ñu | - | 12 de Octubre de Itauguá | 4:5 d.p. | ||
| 09.09.2022 | 00:30 | Benjamín Aceval | - | Sportivo Ameliano | 4:5 d.p. |
