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| U | Luis Ángel Firpo | - | Isidro Metapán | 1:0 (0:0) | ||
| R | Isidro Metapán | - | Luis Ángel Firpo | 1:3 (1:1) | ||
| U: 05.05.2021 22:30 | R: 09.05.2021 03:15 | Winnaars: Luis Ángel Firpo | ||||
| U | CD Águila | - | Alianza | 0:1 (0:0) | ||
| R | Alianza | - | CD Águila | 2:1 (0:1) | ||
| U: 05.05.2021 23:00 | R: 09.05.2021 23:15 | Winnaars: Alianza | ||||
| U | FAS | - | Municipal Limeño | 2:1 (1:0) | ||
| R | Municipal Limeño | - | FAS | 2:4 (0:0, 2:1) d.p. | ||
| U: 05.05.2021 23:30 | R: 09.05.2021 23:00 | Winnaars: FAS | ||||
| U | Santa Tecla FC | - | Once Municipal | 1:1 (0:0) | ||
| R | Once Municipal | - | Santa Tecla FC | 1:2 (0:0) | ||
| U: 06.05.2021 03:00 | R: 09.05.2021 23:00 | Winnaars: Santa Tecla FC | ||||
