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| U | Jocoro FC | - | CD Águila | 1:2 (1:1) | ||
| R | CD Águila | - | Jocoro FC | 1:1 (1:0) | ||
| U: 10.05.2022 23:15 | R: 15.05.2022 03:00 | Winnaars: CD Águila | ||||
| U | FAS | - | Platense Zacatecoluca | 0:1 (0:0) | ||
| R | Platense Zacatecoluca | - | FAS | 2:1 (1:1) | ||
| U: 10.05.2022 23:15 | R: 15.05.2022 23:00 | Winnaars: Platense Zacatecoluca | ||||
| U | Luis Ángel Firpo | - | Alianza | 1:2 (0:0) | ||
| R | Alianza | - | Luis Ángel Firpo | 2:1 (1:1) | ||
| U: 12.05.2022 03:00 | R: 15.05.2022 23:15 | Winnaars: Alianza | ||||
| U | Isidro Metapán | - | AD Chalatenango | 1:0 (1:0) | ||
| R | AD Chalatenango | - | Isidro Metapán | 1:2 (0:0) | ||
| U: 12.05.2022 03:15 | R: 15.05.2022 03:00 | Winnaars: Isidro Metapán | ||||
