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| U | Dragón | - | FAS | 3:2 (1:1) | ||
| R | FAS | - | Dragón | 3:1 (1:0) | ||
| U: 26.10.2022 23:00 | R: 30.10.2022 22:00 | Winnaars: FAS | ||||
| U | Platense Zacatecoluca | - | Alianza | 1:1 (0:0) | ||
| R | Alianza | - | Platense Zacatecoluca | 0:1 (0:1) | ||
| U: 26.10.2022 23:00 | R: 30.10.2022 22:15 | Winnaars: Platense Zacatecoluca | ||||
| U | Atlético Marte | - | CD Águila | 0:0 (0:0) | ||
| R | CD Águila | - | Atlético Marte | 1:0 (0:0) | ||
| U: 27.10.2022 03:30 | R: 30.10.2022 22:00 | Winnaars: CD Águila | ||||
| U | Isidro Metapán | - | Jocoro FC | 1:1 (1:0) | ||
| R | Jocoro FC | - | Isidro Metapán | 4:2 (0:0, 0:0) d.p. | ||
| U: 28.10.2022 03:30 | R: 30.10.2022 22:00 | Winnaars: Jocoro FC | ||||
