| 1. Ronde | 04.09.2021 | UP Langreo | - | Bergantiños FC | 3:0 |  |
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| 2. Ronde | 12.09.2021 | CD Arenteiro | - | UP Langreo | 1:1 | ||||
| 9. Ronde | 30.10.2021 | UP Langreo | - | Real Avilés | 2:1 | ||||
| 10. Ronde | 07.11.2021 | Arosa SC | - | UP Langreo | 1:3 |  |
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| 11. Ronde | 13.11.2021 | CD Cristo Atlético | - | UP Langreo | 2:1 |  |
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| 13. Ronde | 28.11.2021 | Salamanca CF UDS | - | UP Langreo | 1:0 | |
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| 14. Ronde | 04.12.2021 | UP Langreo | - | Pontevedra CF | 1:2 | ||||
| 15. Ronde | 12.12.2021 | SD Compostela | - | UP Langreo | 1:0 | ||||
| 16. Ronde | 18.12.2021 | UP Langreo | - | CD Móstoles URJC | 1:0 | |
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Spanje