| 1. Ronde | 05.09.2021 | CD El Ejido 2012 | - | UD Alzira | 1:1 | ||||
| 2. Ronde | 12.09.2021 | UD Alzira | - | CF La Nucía | 2:2 | ||||
| 3. Ronde | 19.09.2021 | CD Eldense | - | UD Alzira | 1:1 | ||||
| 5. Ronde | 03.10.2021 | Real Murcia | - | UD Alzira | 1:0 | ||||
| 6. Ronde | 10.10.2021 | UD Alzira | - | UD Melilla | 0:1 | ||||
| 7. Ronde | 17.10.2021 | Águilas FC | - | UD Alzira | 2:2 | ||||
| 8. Ronde | 24.10.2021 | UD Alzira | - | Atlético Mancha Real | 0:0 | ||||
| 9. Ronde | 31.10.2021 | CD Toledo | - | UD Alzira | 1:2 | ||||
| 10. Ronde | 06.11.2021 | UD Alzira | - | CD Marchamalo | 1:0 | ||||
| 11. Ronde | 14.11.2021 | Recreativo Granada | - | UD Alzira | 0:1 | ||||
| 12. Ronde | 21.11.2021 | UD Alzira | - | CF Intercity | 0:0 | ||||
| 13. Ronde | 28.11.2021 | Mar Menor CF | - | UD Alzira | 1:0 |  |
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| 14. Ronde | 05.12.2021 | UD Alzira | - | CS Puertollano CF | 2:1 | ||||
| 15. Ronde | 12.12.2021 | UD Alzira | - | UD Socuéllamos | 3:0 | ||||
| 16. Ronde | 19.12.2021 | CA Pulpileño | - | UD Alzira | 1:1 |
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