| 1. Ronde | 05.09.2021 | Real Murcia | - | CD Marchamalo | 3:2 | ||||
| 2. Ronde | 12.09.2021 | CD Marchamalo | - | UD Melilla | 0:0 |  |
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| 3. Ronde | 19.09.2021 | Águilas FC | - | CD Marchamalo | 2:0 | ||||
| 8. Ronde | 24.10.2021 | CF Intercity | - | CD Marchamalo | 3:0 | ||||
| 9. Ronde | 31.10.2021 | CD Marchamalo | - | Mar Menor CF | 2:0 | ||||
| 10. Ronde | 06.11.2021 | UD Alzira | - | CD Marchamalo | 1:0 | ||||
| 12. Ronde | 21.11.2021 | CA Pulpileño | - | CD Marchamalo | 1:1 | ||||
| 13. Ronde | 27.11.2021 | CD Marchamalo | - | Levante UD B | 1:7 | |
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| 14. Ronde | 05.12.2021 | CD El Ejido 2012 | - | CD Marchamalo | 2:2 | ||||
| 15. Ronde | 12.12.2021 | CD Marchamalo | - | CF La Nucía | 0:3 |
Spanje