| 1. Ronde | 23.08.2021 | Sampdoria | - | AC Milan | 0:1 | ||||
| 2. Ronde | 29.08.2021 | Sassuolo Calcio | - | Sampdoria | 0:0 | ||||
| 3. Ronde | 12.09.2021 | Sampdoria | - | Inter | 2:2 |  |
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| 4. Ronde | 19.09.2021 | Empoli FC | - | Sampdoria | 0:3 | ||||
| 5. Ronde | 23.09.2021 | Sampdoria | - | SSC Napoli | 0:4 | ||||
| 6. Ronde | 26.09.2021 | Juventus | - | Sampdoria | 3:2 | ||||
| 7. Ronde | 03.10.2021 | Sampdoria | - | Udinese Calcio | 3:3 | ||||
| 8. Ronde | 17.10.2021 | Cagliari Calcio | - | Sampdoria | 3:1 | ||||
| 9. Ronde | 22.10.2021 | Sampdoria | - | Spezia Calcio | 2:1 | ||||
| 10. Ronde | 27.10.2021 | Sampdoria | - | Atalanta | 1:3 | ||||
| 11. Ronde | 30.10.2021 | Torino FC | - | Sampdoria | 3:0 |  |
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| 14. Ronde | 27.11.2021 | Sampdoria | - | Hellas Verona | 3:1 | ||||
| 15. Ronde | 30.11.2021 | ACF Fiorentina | - | Sampdoria | 3:1 | ||||
| 16. Ronde | 05.12.2021 | Sampdoria | - | Lazio | 1:3 | |
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| 17. Ronde | 10.12.2021 | Genoa CFC | - | Sampdoria | 1:3 | ||||
| 18. Ronde | 19.12.2021 | Sampdoria | - | Venezia FC | 1:1 | |
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| 19. Ronde | 22.12.2021 | AS Roma | - | Sampdoria | 1:1 |
Frankrijk
