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| 01.10.2021 | 20:45 | Cagliari Calcio | - | Venezia FC | 1:1 (1:0) | |
| 02.10.2021 | 15:00 | US Salernitana 1919 | - | Genoa CFC | 1:0 (0:0) | |
| 18:00 | Torino FC | - | Juventus | 0:1 (0:0) | ||
| 20:45 | Sassuolo Calcio | - | Inter | 1:2 (1:0) | ||
| 03.10.2021 | 12:30 | Bologna FC | - | Lazio Roma | 3:0 (2:0) | |
| 15:00 | Hellas Verona | - | Spezia Calcio | 4:0 (3:0) | ||
| 15:00 | Sampdoria | - | Udinese Calcio | 3:3 (1:2) | ||
| 18:00 | ACF Fiorentina | - | SSC Napoli | 1:2 (1:1) | ||
| 18:00 | AS Roma | - | Empoli FC | 2:0 (1:0) | ||
| 20:45 | Atalanta | - | AC Milan | 2:3 (0:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Napoli | 7 | 7 | 0 | 0 | 18:3 | 15 | 21 |
| 2 |
|
AC Milan | 7 | 6 | 1 | 0 | 15:5 | 10 | 19 |
| 3 |
|
Inter | 7 | 5 | 2 | 0 | 22:8 | 14 | 17 |
| 4 |
|
AS Roma | 7 | 5 | 0 | 2 | 16:8 | 8 | 15 |
| 5 |
|
ACF Fiorentina | 7 | 4 | 0 | 3 | 10:11 | -1 | 12 |
| 6 |
|
Lazio Roma | 7 | 3 | 2 | 2 | 15:12 | 3 | 11 |
| 7 |
|
Juventus | 7 | 3 | 2 | 2 | 11:10 | 1 | 11 |
| 8 |
|
Atalanta | 7 | 3 | 2 | 2 | 10:9 | 1 | 11 |
| 9 |
|
Bologna FC | 7 | 3 | 2 | 2 | 12:14 | -2 | 11 |
| 10 |
|
Empoli FC | 7 | 3 | 0 | 4 | 9:12 | -3 | 9 |
| 11 |
|
Torino FC | 7 | 2 | 2 | 3 | 9:7 | 2 | 8 |
| 12 |
|
Hellas Verona | 7 | 2 | 2 | 3 | 15:14 | 1 | 8 |
| 13 |
|
Udinese Calcio | 7 | 2 | 2 | 3 | 9:11 | -2 | 8 |
| 14 |
|
Sassuolo Calcio | 7 | 2 | 1 | 4 | 7:9 | -2 | 7 |
| 15 |
|
Sampdoria | 7 | 1 | 3 | 3 | 10:13 | -3 | 6 |
| 16 |
|
Genoa CFC | 7 | 1 | 2 | 4 | 10:16 | -6 | 5 |
| 17 |
|
Venezia FC | 7 | 1 | 2 | 4 | 5:12 | -7 | 5 |
| 18 |
|
US Salernitana 1919 | 7 | 1 | 1 | 5 | 5:15 | -10 | 4 |
| 19 |
|
Spezia Calcio | 7 | 1 | 1 | 5 | 8:19 | -11 | 4 |
| 20 |
|
Cagliari Calcio | 7 | 0 | 3 | 4 | 8:16 | -8 | 3 |
| Champions League | |
| Europa League | |
| Degradatie |
