| 2. Ronde | 28.01.2021 | Peñarol | - | Defensor Sporting | 1:2 | ||||
| 3. Ronde | 31.01.2021 | Danubio | - | Peñarol | 0:1 | ||||
| 4. Ronde | 03.02.2021 | Peñarol | - | Nacional | 0:0 | ||||
| 5. Ronde | 07.02.2021 | Boston River | - | Peñarol | 1:2 |  |
 |
||
| 6. Ronde | 12.02.2021 | Peñarol | - | Deportivo Maldonado | 1:1 | |
|||
| 7. Ronde | 14.02.2021 | Rentistas | - | Peñarol | 0:1 | ||||
| 8. Ronde | 17.02.2021 | Cerro Largo | - | Peñarol | 1:1 | |
|||
| 9. Ronde | 21.02.2021 | Montevideo Wanderers | - | Peñarol | 0:1 | ||||
| 10. Ronde | 26.02.2021 | Liverpool | - | Peñarol | 1:1 | ||||
| 11. Ronde | 07.03.2021 | Peñarol | - | River Plate | 2:0 | |
|||
| 12. Ronde | 15.03.2021 | Montevideo City Torque | - | Peñarol | 1:2 | |
|||
| 13. Ronde | 20.03.2021 | Peñarol | - | Plaza Colonia | 1:3 | ||||
| 14. Ronde | 25.03.2021 | Progreso | - | Peñarol | 0:2 | |
|||
| 15. Ronde | 30.03.2021 | Peñarol | - | Fénix | 3:1 | |
|
Uruguay