| 4. Ronde | 06.02.2022 | UANL Tigres [U20] | - | Mazatlán FC [U20] | 3:2 | ||||
| 2. Ronde | 16.02.2022 | Mazatlán FC [U20] | - | CF América [U20] | 2:1 | ||||
| 6. Ronde | 20.02.2022 | Gallos Blancos [U20] | - | Mazatlán FC [U20] | 0:0 |  |
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| 7. Ronde | 24.02.2022 | CF Pachuca [U20] | - | Mazatlán FC [U20] | 3:2 | ||||
| 8. Ronde | 01.03.2022 | Mazatlán FC [U20] | - | Club Necaxa [U20] | 1:3 |  |
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| 11. Ronde | 20.03.2022 | Mazatlán FC [U20] | - | Club León [U20] | 1:0 | ||||
| 9. Ronde | 27.03.2022 | Pumas UNAM [U20] | - | Mazatlán FC [U20] | 3:0 | ||||
| 12. Ronde | 01.04.2022 | Atlético San Luis [U20] | - | Mazatlán FC [U20] | 1:2 | |
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| 13. Ronde | 08.04.2022 | Mazatlán FC [U20] | - | Cruz Azul [U20] | 0:0 |
Mexico