| 1. Ronde | 08.01.2022 | Cruz Azul [U20] | - | Club Tijuana [U20] | 0:1 | ||||
| 2. Ronde | 15.01.2022 | Cruz Azul [U20] | - | FC Juárez [U20] | 0:0 | ||||
| 3. Ronde | 22.01.2022 | CF Monterrey [U20] | - | Cruz Azul [U20] | 2:2 |  |
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| 4. Ronde | 07.02.2022 | Club León [U20] | - | Cruz Azul [U20] | 2:1 | ||||
| 5. Ronde | 12.02.2022 | Cruz Azul [U20] | - | Club Necaxa [U20] | 0:1 | ||||
| 6. Ronde | 20.02.2022 | Deportivo Toluca [U20] | - | Cruz Azul [U20] | 1:1 | ||||
| 7. Ronde | 27.02.2022 | Cruz Azul [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 8. Ronde | 02.03.2022 | UANL Tigres [U20] | - | Cruz Azul [U20] | 1:1 | ||||
| 9. Ronde | 05.03.2022 | Cruz Azul [U20] | - | Puebla FC [U20] | 3:0 | ||||
| 10. Ronde | 12.03.2022 | Cruz Azul [U20] | - | Pumas UNAM [U20] | 1:0 Toeg. | ||||
| 11. Ronde | 19.03.2022 | CF Pachuca [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 12. Ronde | 02.04.2022 | Cruz Azul [U20] | - | Atlas Guadalajara [U20] | 1:0 |  |
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| 13. Ronde | 08.04.2022 | Mazatlán FC [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 14. Ronde | 16.04.2022 | Cruz Azul [U20] | - | Deportivo Guadalajara [U20] | 2:1 | ||||
| 15. Ronde | 21.04.2022 | Gallos Blancos [U20] | - | Cruz Azul [U20] | 1:3 | ||||
| 16. Ronde | 24.04.2022 | Cruz Azul [U20] | - | Atlético San Luis [U20] | 2:2 |
Mexico