| 14. Ronde | 05.12.2021 | UD Alzira | - | CS Puertollano CF | 2:1 | ||||
| 15. Ronde | 12.12.2021 | CS Puertollano CF | - | UD Melilla | 1:0 | ||||
| 17. Ronde | 09.01.2022 | Águilas FC | - | CS Puertollano CF | 1:0 | ||||
| 24. Ronde | 06.03.2022 | CF La Nucía | - | CS Puertollano CF | 3:2 | ||||
| 29. Ronde | 10.04.2022 | CS Puertollano CF | - | Mar Menor CF | 4:0 |
Spanje