| 3. Ronde | 07.08.2021 | Santos Laguna [U16] | - | UANL Tigres [U16] | 3:1 | ||||
| 4. Ronde | 14.08.2021 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 0:0 | ||||
| 7. Ronde | 04.09.2021 | Santos Laguna [U16] | - | Club León [U16] | 1:0 | ||||
| 8. Ronde | 11.09.2021 | Santos Laguna [U16] | - | Mazatlán FC [U16] | 4:2 | ||||
| 9. Ronde | 18.09.2021 | Club Necaxa [U16] | - | Santos Laguna [U16] | 1:1 | ||||
| 10. Ronde | 25.09.2021 | Santos Laguna [U16] | - | Atlas Guadalajara [U16] | 1:2 | ||||
| 11. Ronde | 02.10.2021 | Atlético San Luis [U16] | - | Santos Laguna [U16] | 0:3 | ||||
| 12. Ronde | 09.10.2021 | Mazatlán FC [U16] | - | Santos Laguna [U16] | 1:2 |  |
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| 13. Ronde | 16.10.2021 | Santos Laguna [U16] | - | CF Monterrey [U16] | 1:1 | ||||
| 15. Ronde | 30.10.2021 | Santos Laguna [U16] | - | Club Necaxa [U16] | 2:1 |  |
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| 17. Ronde | 13.11.2021 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 0:1 | ||||
| 18. Ronde | 20.11.2021 | Club León [U16] | - | Santos Laguna [U16] | 0:1 |
Mexico