| 1. Ronde | 09.01.2022 | Pumas UNAM [U20] | - | Deportivo Toluca [U20] | 1:1 |  |
|||
| 2. Ronde | 14.01.2022 | Gallos Blancos [U20] | - | Pumas UNAM [U20] | 0:1 | ||||
| 4. Ronde | 06.02.2022 | Club Tijuana [U20] | - | Pumas UNAM [U20] | 1:1 | ||||
| 5. Ronde | 13.02.2022 | Pumas UNAM [U20] | - | Club León [U20] | 2:1 | ||||
| 10. Ronde | 12.03.2022 | Cruz Azul [U20] | - | Pumas UNAM [U20] | 1:0 Toeg. | ||||
| 11. Ronde | 19.03.2022 | Pumas UNAM [U20] | - | Club Necaxa [U20] | 1:2 | ||||
| 15. Ronde | 20.04.2022 | Atlético San Luis [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 17. Ronde | 01.05.2022 | Pumas UNAM [U20] | - | CF Pachuca [U20] | 2:1 |
Mexico