| 2. Ronde | 12.09.2021 | Antequera CF | - | Don Benito | 2:1 |  |
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| 11. Ronde | 14.11.2021 | Don Benito | - | Vélez CF | 4:1 | ||||
| 12. Ronde | 21.11.2021 | Xerez DFC | - | Don Benito | 1:0 | |
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| 13. Ronde | 27.11.2021 | Don Benito | - | Cádiz CF B | 2:3 | ||||
| 14. Ronde | 05.12.2021 | CD Coria | - | Don Benito | 1:0 | ||||
| 15. Ronde | 12.12.2021 | UD Montijo | - | Don Benito | 3:1 | ||||
| 16. Ronde | 19.12.2021 | Don Benito | - | UD Tamaraceite | 2:0 | ||||
| 17. Ronde | 09.01.2022 | UD San Fernando | - | Don Benito | 1:3 | ||||
| 18. Ronde | 23.01.2022 | CD Mensajero | - | Don Benito | 1:2 |  |
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| 19. Ronde | 30.01.2022 | Don Benito | - | Antequera CF | 1:1 | ||||
| 20. Ronde | 06.02.2022 | CD San Roque de Lepe | - | Don Benito | 1:0 | |
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| 21. Ronde | 13.02.2022 | Don Benito | - | Córdoba CF | 1:2 | ||||
| 22. Ronde | 20.02.2022 | CP Cacereño | - | Don Benito | 2:0 | ||||
| 29. Ronde | 10.04.2022 | Don Benito | - | Xerez DFC | 1:2 | ||||
| 30. Ronde | 17.04.2022 | Cádiz CF B | - | Don Benito | 2:1 | |
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| 31. Ronde | 24.04.2022 | Don Benito | - | CD Coria | 3:0 | ||||
| 32. Ronde | 30.04.2022 | Don Benito | - | UD Montijo | 1:0 | ||||
| 34. Ronde | 15.05.2022 | Don Benito | - | UD San Fernando | 2:2 |
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