| 1. Ronde | 24.07.2021 | NK Veres | - | Kolos Kovalivka | 0:0 | ||||
| 2. Ronde | 30.07.2021 | Kolos Kovalivka | - | Metalist 1925 Kharkiv | 1:0 | ||||
| 4. Ronde | 15.08.2021 | Kolos Kovalivka | - | Rukh Lviv | 1:1 | ||||
| 6. Ronde | 28.08.2021 | Dinamo Kiev | - | Kolos Kovalivka | 7:0 |  |
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| 8. Ronde | 18.09.2021 | Inhulets Petrove | - | Kolos Kovalivka | 0:2 | ||||
| 9. Ronde | 24.09.2021 | Kolos Kovalivka | - | Vorskla Poltava | 0:1 | ||||
| 10. Ronde | 02.10.2021 | Kolos Kovalivka | - | Chernomorets Odessa | 2:1 | ||||
| 12. Ronde | 24.10.2021 | Zorya Lugansk | - | Kolos Kovalivka | 1:0 | ||||
| 13. Ronde | 31.10.2021 | Kolos Kovalivka | - | FK Lviv | 0:1 | ||||
| 3. Ronde | 24.11.2021 | FC Mynai | - | Kolos Kovalivka | 1:1 |  |
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| 16. Ronde | 28.11.2021 | Kolos Kovalivka | - | NK Veres | 1:0 | ||||
| 17. Ronde | 04.12.2021 | Metalist 1925 Kharkiv | - | Kolos Kovalivka | 0:1 | ||||
| 18. Ronde | 12.12.2021 | Kolos Kovalivka | - | FC Mynai | 2:1 |
Oekraïne