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| 22.10.2021 | 16:00 | Desna Chernigov | - | FK Oleksandriya | 1:1 (1:1) | |
| 18:30 | Metalist 1925 Kharkiv | - | Inhulets Petrove | 4:0 (1:0) | ||
| 23.10.2021 | 13:00 | NK Veres | - | FK Mariupol | 2:0 (0:0) | |
| 16:00 | Vorskla Poltava | - | Shakhtar Donetsk | 0:2 (0:0) | ||
| 18:30 | Chernomorets Odessa | - | FK Lviv | 1:1 (0:0) | ||
| 24.10.2021 | 13:00 | Rukh Lviv | - | FC Mynai | 2:2 (0:1) | |
| 16:00 | Dinamo Kiev | - | SK Dnipro-1 | 2:0 (0:0) | ||
| 18:30 | Zorya Lugansk | - | Kolos Kovalivka | 1:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Dinamo Kiev | 12 | 10 | 2 | 0 | 31:3 | 28 | 32 |
| 2 |
|
Shakhtar Donetsk | 12 | 9 | 2 | 1 | 31:6 | 25 | 29 |
| 3 |
|
Vorskla Poltava | 12 | 7 | 3 | 2 | 21:10 | 11 | 24 |
| 4 |
|
Zorya Lugansk | 12 | 7 | 2 | 3 | 24:15 | 9 | 23 |
| 5 |
|
SK Dnipro-1 | 12 | 7 | 1 | 4 | 16:14 | 2 | 22 |
| 6 |
|
FK Oleksandriya | 12 | 5 | 4 | 3 | 12:10 | 2 | 19 |
| 7 |
|
Metalist 1925 Kharkiv | 12 | 6 | 1 | 5 | 15:14 | 1 | 19 |
| 8 |
|
NK Veres | 12 | 5 | 3 | 4 | 12:12 | 0 | 18 |
| 9 |
|
Desna Chernigov | 12 | 5 | 3 | 4 | 14:17 | -3 | 18 |
| 10 |
|
Rukh Lviv | 11 | 3 | 3 | 5 | 10:14 | -4 | 12 |
| 11 |
|
Kolos Kovalivka | 12 | 3 | 3 | 6 | 8:18 | -10 | 12 |
| 12 |
|
FC Mynai | 12 | 1 | 6 | 5 | 9:15 | -6 | 9 |
| 13 |
|
Inhulets Petrove | 11 | 2 | 2 | 7 | 9:22 | -13 | 8 |
| 14 |
|
FK Lviv | 12 | 1 | 4 | 7 | 8:20 | -12 | 7 |
| 15 |
|
Chernomorets Odessa | 12 | 1 | 4 | 7 | 12:26 | -14 | 7 |
| 16 |
|
FK Mariupol | 12 | 1 | 1 | 10 | 13:29 | -16 | 4 |
| Champions League Kwali. | |
| Promotie en degradatie | |
| Degradatie |
