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| 01.10.2021 | 18:30 | FK Mariupol | - | Rukh Lviv | 0:2 (0:2) | |
| 02.10.2021 | 13:00 | Kolos Kovalivka | - | Chernomorets Odessa | 2:1 (1:1) | |
| 16:00 | FK Lviv | - | SK Dnipro-1 | 0:1 (0:1) | ||
| 18:30 | Vorskla Poltava | - | Inhulets Petrove | 3:0 (0:0) | ||
| 03.10.2021 | 13:00 | NK Veres | - | FK Oleksandriya | 0:0 (0:0) | |
| 16:00 | Zorya Lugansk | - | Desna Chernigov | 2:0 (1:0) | ||
| 16:00 | Metalist 1925 Kharkiv | - | FC Mynai | 1:0 (0:0) | ||
| 18:30 | Dinamo Kiev | - | Shakhtar Donetsk | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Dinamo Kiev | 10 | 8 | 2 | 0 | 25:2 | 23 | 26 |
| 2 |
|
Shakhtar Donetsk | 10 | 7 | 2 | 1 | 23:5 | 18 | 23 |
| 3 |
|
Vorskla Poltava | 10 | 6 | 3 | 1 | 19:7 | 12 | 21 |
| 4 |
|
Zorya Lugansk | 10 | 6 | 2 | 2 | 22:9 | 13 | 20 |
| 5 |
|
SK Dnipro-1 | 10 | 6 | 1 | 3 | 14:12 | 2 | 19 |
| 6 |
|
FK Oleksandriya | 10 | 5 | 3 | 2 | 10:7 | 3 | 18 |
| 7 |
|
Desna Chernigov | 10 | 5 | 1 | 4 | 13:16 | -3 | 16 |
| 8 |
|
Metalist 1925 Kharkiv | 10 | 4 | 1 | 5 | 9:13 | -4 | 13 |
| 9 |
|
NK Veres | 10 | 3 | 3 | 4 | 9:12 | -3 | 12 |
| 10 |
|
Kolos Kovalivka | 10 | 3 | 3 | 4 | 8:15 | -7 | 12 |
| 11 |
|
Rukh Lviv | 10 | 3 | 2 | 5 | 8:12 | -4 | 11 |
| 12 |
|
Inhulets Petrove | 10 | 2 | 2 | 6 | 9:18 | -9 | 8 |
| 13 |
|
FC Mynai | 10 | 1 | 4 | 5 | 7:13 | -6 | 7 |
| 14 |
|
FK Lviv | 10 | 1 | 3 | 6 | 6:15 | -9 | 6 |
| 15 |
|
Chernomorets Odessa | 10 | 1 | 3 | 6 | 11:24 | -13 | 6 |
| 16 |
|
FK Mariupol | 10 | 1 | 1 | 8 | 12:25 | -13 | 4 |
| Champions League Kwali. | |
| Promotie en degradatie | |
| Degradatie |
