| 1. Ronde | 25.06.2022 | Pumas UNAM [] | - | Cruz Azul [] | 3:2 | ||||
| 2. Ronde | 02.07.2022 | Gallos Blancos [] | - | Pumas UNAM [] | 1:2 |  |
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| 3. Ronde | 09.07.2022 | Pumas UNAM [] | - | Deportivo Toluca [] | 3:3 | ||||
| 4. Ronde | 16.07.2022 | Club Necaxa [] | - | Pumas UNAM [] | 0:1 | ||||
| 6. Ronde | 30.07.2022 | Pumas UNAM [] | - | CF Pachuca [] | 1:0 | ||||
| 7. Ronde | 06.08.2022 | FC Juárez [] | - | Pumas UNAM [] | 3:4 | ||||
| 8. Ronde | 13.08.2022 | Pumas UNAM [] | - | CF América [] | 3:0 | ||||
| 9. Ronde | 20.08.2022 | Puebla FC [] | - | Pumas UNAM [] | 1:2 | ||||
| 10. Ronde | 27.08.2022 | Cruz Azul [] | - | Pumas UNAM [] | 0:4 | ||||
| 11. Ronde | 03.09.2022 | Pumas UNAM [] | - | Gallos Blancos [] | 3:0 | |
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| 12. Ronde | 10.09.2022 | Deportivo Toluca [] | - | Pumas UNAM [] | 1:0 | ||||
| 13. Ronde | 17.09.2022 | Pumas UNAM [] | - | Club Necaxa [] | 2:1 | ||||
| 15. Ronde | 01.10.2022 | CF Pachuca [] | - | Pumas UNAM [] | 3:3 | ||||
| 17. Ronde | 15.10.2022 | CF América [] | - | Pumas UNAM [] | 2:1 | ||||
| 18. Ronde | 22.10.2022 | Pumas UNAM [] | - | Puebla FC [] | 1:0 |
Mexico