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| 16.07.2022 | 18:15 | Deportivo Guadalajara | - | Club León | 2:1 (0:1) | |
| 18:30 | Club Necaxa | - | Pumas UNAM | 0:1 (0:0) | ||
| 18:30 | Deportivo Toluca | - | CF Pachuca | 0:0 (0:0) | ||
| 18:30 | Cruz Azul | - | CF América | 3:2 (1:1) | ||
| 18:30 | Gallos Blancos | - | FC Juárez | 4:0 (2:0) | ||
| 18:30 | CF Monterrey | - | Atlas Guadalajara | 1:1 (1:0) | ||
| 18:45 | Atlético San Luis | - | Santos Laguna | 2:7 (1:5) | ||
| 21:45 | Club Tijuana | - | UANL Tigres | 8:2 (6:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 4 | 3 | 1 | 0 | 9:6 | 3 | 10 |
| 2 |
|
CF Pachuca | 4 | 2 | 2 | 0 | 5:1 | 4 | 8 |
| 3 |
|
Cruz Azul | 4 | 2 | 0 | 2 | 10:10 | 0 | 6 |
| 4 |
|
Deportivo Toluca | 3 | 1 | 2 | 0 | 5:3 | 2 | 5 |
| 5 |
|
Gallos Blancos | 4 | 1 | 1 | 2 | 5:5 | 0 | 4 |
| 6 |
|
Puebla FC | 3 | 1 | 0 | 2 | 7:7 | 0 | 3 |
| 7 |
|
Club Necaxa | 3 | 1 | 0 | 2 | 3:3 | 0 | 3 |
| 8 |
|
CF América | 3 | 1 | 0 | 2 | 6:8 | -2 | 3 |
| 9 |
|
FC Juárez | 4 | 1 | 0 | 3 | 5:12 | -7 | 3 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Tijuana | 4 | 3 | 1 | 0 | 13:2 | 11 | 10 |
| 2 |
|
CF Monterrey | 4 | 3 | 1 | 0 | 15:5 | 10 | 10 |
| 3 |
|
Deportivo Guadalajara | 4 | 3 | 0 | 1 | 5:4 | 1 | 9 |
| 4 |
|
Atlas Guadalajara | 4 | 2 | 2 | 0 | 6:2 | 4 | 8 |
| 5 |
|
Santos Laguna | 4 | 1 | 0 | 3 | 10:10 | 0 | 3 |
| 6 |
|
Club León | 3 | 1 | 0 | 2 | 4:4 | 0 | 3 |
| 7 |
|
Atlético San Luis | 3 | 1 | 0 | 2 | 4:13 | -9 | 3 |
| 8 |
|
Mazatlán FC | 3 | 0 | 0 | 3 | 2:9 | -7 | 0 |
| 9 |
|
UANL Tigres | 3 | 0 | 0 | 3 | 2:12 | -10 | 0 |
| Play-offs | |
| Play-offs |
