| 1. Ronde | 29.08.2021 | UCAM Murcia CF | - | UE Costa Brava | 1:1 | ||||
| 2. Ronde | 04.09.2021 | Real Betis B | - | UCAM Murcia CF | 1:0 | ||||
| 3. Ronde | 10.09.2021 | UCAM Murcia CF | - | Real Madrid Castilla | 3:0 | ||||
| 4. Ronde | 18.09.2021 | Linares Deportivo | - | UCAM Murcia CF | 1:2 |  |
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| 5. Ronde | 25.09.2021 | UCAM Murcia CF | - | FC Andorra | 1:1 | ||||
| 6. Ronde | 02.10.2021 | RB Linense | - | UCAM Murcia CF | 2:0 | ||||
| 7. Ronde | 09.10.2021 | UCAM Murcia CF | - | CD Castellón | 0:1 | |
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| 8. Ronde | 15.10.2021 | CD Alcoyano | - | UCAM Murcia CF | 3:2 | ||||
| 9. Ronde | 23.10.2021 | UCAM Murcia CF | - | Sevilla Atlético | 2:1 | ||||
| 10. Ronde | 31.10.2021 | CE Sabadell | - | UCAM Murcia CF | 1:1 | ||||
| 12. Ronde | 14.11.2021 | Gimnàstic de Tarragona | - | UCAM Murcia CF | 2:2 | ||||
| 13. Ronde | 21.11.2021 | Atlético Baleares | - | UCAM Murcia CF | 3:0 | ||||
| 14. Ronde | 28.11.2021 | UCAM Murcia CF | - | Algeciras CF | 2:0 | |
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| 15. Ronde | 04.12.2021 | San Fernando CD | - | UCAM Murcia CF | 2:1 | ||||
| 16. Ronde | 12.12.2021 | UCAM Murcia CF | - | Albacete | 1:2 |
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