| 1. Ronde | 04.09.2021 | UP Langreo | - | Bergantiños FC | 3:0 | ||||
| 8. Ronde | 24.10.2021 | CDA Navalcarnero | - | UP Langreo | 1:0 | ||||
| 9. Ronde | 30.10.2021 | UP Langreo | - | Real Avilés | 2:1 | ||||
| 10. Ronde | 07.11.2021 | Arosa SC | - | UP Langreo | 1:3 | ||||
| 11. Ronde | 13.11.2021 | CD Cristo Atlético | - | UP Langreo | 2:1 |  |
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| 12. Ronde | 20.11.2021 | UP Langreo | - | Unión Club Ceares | 1:0 | ||||
| 13. Ronde | 28.11.2021 | Salamanca CF UDS | - | UP Langreo | 1:0 | ||||
| 16. Ronde | 18.12.2021 | UP Langreo | - | CD Móstoles URJC | 1:0 |
Senegal