| 1. Ronde | 08.01.2022 | Pumas UNAM [] | - | Cruz Azul [] | 2:1 | ||||
| 2. Ronde | 15.01.2022 | Cruz Azul [] | - | CF Pachuca [] | 1:4 | ||||
| 3. Ronde | 22.01.2022 | Club Necaxa [] | - | Cruz Azul [] | 4:1 | ||||
| 4. Ronde | 29.01.2022 | Cruz Azul [] | - | Gallos Blancos [] | 0:1 | ||||
| 8. Ronde | 26.02.2022 | Cruz Azul [] | - | Puebla FC [] | 4:1 | ||||
| 9. Ronde | 05.03.2022 | Cruz Azul [] | - | CF América [] | 3:1 | ||||
| 11. Ronde | 19.03.2022 | Gallos Blancos [] | - | Cruz Azul [] | 4:0 | ||||
| 12. Ronde | 26.03.2022 | Cruz Azul [] | - | FC Juárez [] | 0:2 | ||||
| 13. Ronde | 02.04.2022 | Cruz Azul [] | - | Deportivo Toluca [] | 1:1 | ||||
| 16. Ronde | 23.04.2022 | Puebla FC [] | - | Cruz Azul [] | 0:2 | ||||
| 14. Ronde | 27.04.2022 | CF América [] | - | Cruz Azul [] | 6:1 | ||||
| 18. Ronde | 07.05.2022 | Cruz Azul [] | - | Club Necaxa [] | 1:3 |
Mexico