| 4. Ronde | 29.01.2022 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 0:1 |  |
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| 9. Ronde | 05.03.2022 | Santos Laguna [U16] | - | Club Tijuana [U16] | 2:0 | ||||
| 10. Ronde | 12.03.2022 | Atlas Guadalajara [U16] | - | Santos Laguna [U16] | 2:3 | ||||
| 11. Ronde | 19.03.2022 | Santos Laguna [U16] | - | Atlético San Luis [U16] | 2:1 |  |
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| 15. Ronde | 20.04.2022 | Club Tijuana [U16] | - | Santos Laguna [U16] | 0:1 | ||||
| 16. Ronde | 23.04.2022 | Santos Laguna [U16] | - | UANL Tigres [U16] | 5:0 | ||||
| 17. Ronde | 30.04.2022 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 3:0 | ||||
| 18. Ronde | 07.05.2022 | Santos Laguna [U16] | - | Club León [U16] | 2:1 |
Mexico