| 1. Ronde | 04.02.2018 | Defensor Sporting | - | Atenas | 3:0 |  |
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| 3. Ronde | 18.02.2018 | Defensor Sporting | - | Torque | 2:1 | ||||
| 5. Ronde | 04.03.2018 | Defensor Sporting | - | Fénix | 3:2 |  |
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| 6. Ronde | 10.03.2018 | Nacional | - | Defensor Sporting | 2:0 | |
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| 8. Ronde | 24.03.2018 | Defensor Sporting | - | CA Cerro | 2:1 | ||||
| 9. Ronde | 28.03.2018 | Racing | - | Defensor Sporting | 2:2 | ||||
| 10. Ronde | 01.04.2018 | Defensor Sporting | - | River Plate | 5:2 | ||||
| 11. Ronde | 08.04.2018 | Montevideo Wanderers | - | Defensor Sporting | 1:2 | |
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| 12. Ronde | 14.04.2018 | Defensor Sporting | - | Liverpool | 1:0 | |
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| 14. Ronde | 01.05.2018 | Defensor Sporting | - | Boston River | 2:1 | |
Uruguay
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