| 7. Ronde | 11.09.2021 | Paris FC | - | EA Guingamp | 0:1 |  |
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| 8. Ronde | 18.09.2021 | Chamois Niortais | - | EA Guingamp | 2:0 | ||||
| 12. Ronde | 16.10.2021 | AS Nancy Lorraine | - | EA Guingamp | 2:1 |  |
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| 13. Ronde | 23.10.2021 | EA Guingamp | - | Nîmes Olympique | 3:1 | ||||
| 14. Ronde | 30.10.2021 | Toulouse FC | - | EA Guingamp | 2:2 | ||||
| 15. Ronde | 06.11.2021 | EA Guingamp | - | SC Bastia | 2:3 | |
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| 16. Ronde | 20.11.2021 | Pau FC | - | EA Guingamp | 2:0 | ||||
| 20. Ronde | 08.01.2022 | Valenciennes FC | - | EA Guingamp | 1:1 | ||||
| 21. Ronde | 15.01.2022 | EA Guingamp | - | Grenoble Foot 38 | 0:0 | ||||
| 22. Ronde | 22.01.2022 | Amiens SC | - | EA Guingamp | 3:0 | ||||
| 25. Ronde | 19.02.2022 | EA Guingamp | - | Paris FC | 1:1 | ||||
| 26. Ronde | 26.02.2022 | EA Guingamp | - | Chamois Niortais | 1:0 | ||||
| 28. Ronde | 12.03.2022 | EA Guingamp | - | US Quevilly-Rouen | 1:1 | ||||
| 30. Ronde | 19.03.2022 | EA Guingamp | - | AS Nancy Lorraine | 3:1 | ||||
| 33. Ronde | 16.04.2022 | SC Bastia | - | EA Guingamp | 1:2 | ||||
| 34. Ronde | 19.04.2022 | EA Guingamp | - | Pau FC | 3:0 | ||||
| 35. Ronde | 22.04.2022 | Dijon FCO | - | EA Guingamp | 3:3 | ||||
| 36. Ronde | 30.04.2022 | EA Guingamp | - | SM Caen | 2:1 |
Frankrijk
Togo