| 2. Ronde | 15.01.2022 | CF Monterrey [] | - | Deportivo Guadalajara [] | 1:1 | ||||
| 10. Ronde | 12.03.2022 | Atlético San Luis [] | - | Deportivo Guadalajara [] | 0:2 | ||||
| 17. Ronde | 30.04.2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 4:0 | ||||
| 18. Ronde | 07.05.2022 | Deportivo Guadalajara [] | - | UANL Tigres [] | 2:1 |
Mexico