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| 12.03.2022 | 16:00 | CF Pachuca | - | Cruz Azul | 4:2 (1:1) | |
| 17:00 | Mazatlán FC | - | CF Monterrey | 1:3 (0:1) | ||
| 17:45 | Atlético San Luis | - | Deportivo Guadalajara | 0:2 (0:2) | ||
| 18:00 | UANL Tigres | - | Club León | 1:1 (1:1) | ||
| 18:30 | Atlas Guadalajara | - | Santos Laguna | 3:0 (0:0) | ||
| 18:30 | Deportivo Toluca | - | Puebla FC | 2:1 (0:0) | ||
| 19:45 | CF América | - | Gallos Blancos | 0:1 (0:1) | ||
| 16.03.2022 | 16:00 | FC Juárez | - | Pumas UNAM | 1:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 9 | 7 | 2 | 0 | 21:9 | 12 | 23 |
| 2 |
|
CF Pachuca | 9 | 7 | 0 | 2 | 28:11 | 17 | 21 |
| 3 |
|
Club Necaxa | 8 | 4 | 2 | 2 | 18:10 | 8 | 14 |
| 4 |
|
Deportivo Toluca | 9 | 4 | 2 | 3 | 14:13 | 1 | 14 |
| 5 |
|
FC Juárez | 9 | 4 | 1 | 4 | 11:12 | -1 | 13 |
| 6 |
|
Gallos Blancos | 9 | 3 | 2 | 4 | 6:14 | -8 | 11 |
| 7 |
|
CF América | 9 | 2 | 1 | 6 | 11:15 | -4 | 7 |
| 8 |
|
Cruz Azul | 9 | 2 | 1 | 6 | 14:21 | -7 | 7 |
| 9 |
|
Puebla FC | 9 | 1 | 1 | 7 | 5:23 | -18 | 4 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 9 | 6 | 3 | 0 | 18:5 | 13 | 21 |
| 2 |
|
Atlas Guadalajara | 9 | 6 | 1 | 2 | 26:12 | 14 | 19 |
| 3 |
|
UANL Tigres | 9 | 6 | 1 | 2 | 16:12 | 4 | 19 |
| 4 |
|
Santos Laguna | 9 | 5 | 2 | 2 | 16:12 | 4 | 17 |
| 5 |
|
CF Monterrey | 9 | 4 | 2 | 3 | 18:10 | 8 | 14 |
| 6 |
|
Club Tijuana | 8 | 4 | 1 | 3 | 16:11 | 5 | 13 |
| 7 |
|
Club León | 9 | 1 | 3 | 5 | 9:19 | -10 | 6 |
| 8 |
|
Atlético San Luis | 9 | 1 | 0 | 8 | 2:24 | -22 | 3 |
| 9 |
|
Mazatlán FC | 9 | 0 | 1 | 8 | 7:23 | -16 | 1 |
| Play-offs | |
| Play-offs |
