| 7. Ronde | 02.04.2022 | Cobreloa | - | Puerto Montt | 2:1 | ||||
| 8. Ronde | 09.04.2022 | Deportes Melipilla | - | Cobreloa | 0:0 | ||||
| 9. Ronde | 17.04.2022 | Deportes Iquique | - | Cobreloa | 2:0 | ||||
| 10. Ronde | 21.04.2022 | Cobreloa | - | Barnechea | 3:2 | ||||
| 11. Ronde | 24.04.2022 | Cobreloa | - | Recoleta | 3:0 | ||||
| 12. Ronde | 30.04.2022 | Unión San Felipe | - | Cobreloa | 1:1 | ||||
| 16. Ronde | 22.05.2022 | Cobreloa | - | Fernández Vial | 1:0 | ||||
| 17. Ronde | 28.05.2022 | Santiago Morning | - | Cobreloa | 0:1 | ||||
| 5. Ronde | 02.06.2022 | Cobreloa | - | Santa Cruz | 1:0 |  |
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| 21. Ronde | 24.07.2022 | Cobreloa | - | Rangers | 1:0 | ||||
| 24. Ronde | 12.08.2022 | Puerto Montt | - | Cobreloa | 1:1 | ||||
| 26. Ronde | 31.08.2022 | Cobreloa | - | Deportes Iquique | 2:1 | ||||
| 29. Ronde | 26.09.2022 | Cobreloa | - | Unión San Felipe | 1:0 | ||||
| 33. Ronde | 23.10.2022 | Fernández Vial | - | Cobreloa | 2:3 | ||||
| 34. Ronde | 01.11.2022 | Cobreloa | - | Santiago Morning | 2:2 |
Chili