| 1. Ronde | 28.08.2021 | SD Logroñés | - | Real Valladolid B | 1:1 | ||||
| 9. Ronde | 23.10.2021 | Real Valladolid B | - | Rayo Majadahonda | 0:1 | ||||
| 11. Ronde | 06.11.2021 | Real Valladolid B | - | CD Calahorra | 1:1 | ||||
| 13. Ronde | 20.11.2021 | Real Valladolid B | - | Inter de Madrid | 2:2 |  |
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| 14. Ronde | 26.11.2021 | UD Logroñés | - | Real Valladolid B | 3:2 | |
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| 15. Ronde | 05.12.2021 | Real Valladolid B | - | Racing Santander | 3:0 | |
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| 16. Ronde | 12.12.2021 | Deportivo La Coruña | - | Real Valladolid B | 3:0 | ||||
| 19. Ronde | 22.01.2022 | Real Valladolid B | - | CD Tudelano | 0:2 | ||||
| 22. Ronde | 05.02.2022 | Real Valladolid B | - | Celta de Vigo B | 1:3 | ||||
| 25. Ronde | 25.02.2022 | Athletic Club B | - | Real Valladolid B | 3:0 | ||||
| 21. Ronde | 02.03.2022 | Real Unión | - | Real Valladolid B | 2:1 | |
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| 26. Ronde | 06.03.2022 | Real Valladolid B | - | UD Logroñés | 0:2 | ||||
| 37. Ronde | 21.05.2022 | Real Valladolid B | - | Deportivo La Coruña | 0:4 | |
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