| 4. Ronde | 29.01.2022 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:0 |  |
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| 8. Ronde | 26.02.2022 | Mazatlán FC [] | - | Santos Laguna [] | 0:3 | ||||
| 9. Ronde | 05.03.2022 | Santos Laguna [] | - | Club Tijuana [] | 2:1 | ||||
| 10. Ronde | 12.03.2022 | Atlas Guadalajara [] | - | Santos Laguna [] | 3:0 | |
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| 11. Ronde | 19.03.2022 | Santos Laguna [] | - | Atlético San Luis [] | 2:2 | ||||
| 12. Ronde | 26.03.2022 | Santos Laguna [] | - | Mazatlán FC [] | 3:2 | ||||
| 13. Ronde | 03.04.2022 | CF Monterrey [] | - | Santos Laguna [] | 2:0 | ||||
| 15. Ronde | 20.04.2022 | Club Tijuana [] | - | Santos Laguna [] | 4:1 | |
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| 17. Ronde | 30.04.2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 4:0 | ||||
| 18. Ronde | 07.05.2022 | Santos Laguna [] | - | Club León [] | 2:3 | |
Mexico