| 1. Ronde | 25.06.2022 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:1 |  |
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| 2. Ronde | 03.07.2022 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 1:3 | ||||
| 3. Ronde | 09.07.2022 | UANL Tigres [] | - | Deportivo Guadalajara [] | 0:1 | ||||
| 4. Ronde | 16.07.2022 | Deportivo Guadalajara [] | - | Club León [] | 2:1 | ||||
| 6. Ronde | 31.07.2022 | Club Tijuana [] | - | Deportivo Guadalajara [] | 3:1 | ||||
| 7. Ronde | 06.08.2022 | Deportivo Guadalajara [] | - | CF Monterrey [] | 0:1 | ||||
| 8. Ronde | 13.08.2022 | Atlético San Luis [] | - | Deportivo Guadalajara [] | 2:1 | ||||
| 10. Ronde | 28.08.2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 1:1 | ||||
| 11. Ronde | 03.09.2022 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 2:8 | ||||
| 13. Ronde | 16.09.2022 | CF Monterrey [] | - | Deportivo Guadalajara [] | 0:2 | ||||
| 17. Ronde | 15.10.2022 | Deportivo Guadalajara [] | - | UANL Tigres [] | 6:1 | |
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| 18. Ronde | 22.10.2022 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 1:0 |
Mexico