| 1. Ronde | 08.01.2022 | Club Tijuana [U16] | - | Club León [U16] | 2:2 |  |
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| 8. Ronde | 26.02.2022 | Atlas Guadalajara [U16] | - | Club León [U16] | 5:0 | ||||
| 9. Ronde | 05.03.2022 | Club León [U16] | - | Mazatlán FC [U16] | 4:0 | |
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| 10. Ronde | 12.03.2022 | UANL Tigres [U16] | - | Club León [U16] | 2:1 | |
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| 12. Ronde | 26.03.2022 | Club León [U16] | - | Deportivo Guadalajara [U16] | 0:3 |  |
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| 15. Ronde | 16.04.2022 | Atlético San Luis [U16] | - | Club León [U16] | 1:3 | |
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| 17. Ronde | 30.04.2022 | Club León [U16] | - | CF Monterrey [U16] | 1:2 | |
Mexico