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| 26.03.2022 | 16:00 | Atlético San Luis | - | CF Monterrey | 1:1 (1:1) | |
| 16:00 | Santos Laguna | - | Mazatlán FC | 3:1 (1:0) | ||
| 16:00 | Club León | - | Deportivo Guadalajara | 0:3 (0:2) | ||
| 16:00 | Deportivo Toluca | - | Gallos Blancos | 2:0 (0:0) | ||
| 16:00 | Cruz Azul | - | FC Juárez | 7:3 (3:1) | ||
| 18:00 | CF Pachuca | - | Pumas UNAM | 0:0 (0:0) | ||
| 19:00 | Club Tijuana | - | UANL Tigres | 2:1 (2:0) | ||
| 23:00 | Puebla FC | - | Club Necaxa | 2:3 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cruz Azul | 11 | 7 | 2 | 2 | 29:16 | 13 | 23 |
| 2 |
|
Pumas UNAM | 11 | 6 | 2 | 3 | 15:8 | 7 | 20 |
| 3 |
|
Deportivo Toluca | 11 | 5 | 2 | 4 | 24:17 | 7 | 17 |
| 4 |
|
CF América | 10 | 5 | 1 | 4 | 14:12 | 2 | 16 |
| 5 |
|
Club Necaxa | 10 | 4 | 4 | 2 | 15:17 | -2 | 16 |
| 6 |
|
Puebla FC | 11 | 4 | 2 | 5 | 19:17 | 2 | 14 |
| 7 |
|
CF Pachuca | 11 | 3 | 5 | 3 | 22:21 | 1 | 14 |
| 8 |
|
FC Juárez | 10 | 2 | 1 | 7 | 14:29 | -15 | 7 |
| 9 |
|
Gallos Blancos | 11 | 1 | 3 | 7 | 7:22 | -15 | 6 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 11 | 8 | 2 | 1 | 26:9 | 17 | 26 |
| 2 |
|
Santos Laguna | 11 | 6 | 2 | 3 | 18:12 | 6 | 20 |
| 3 |
|
Atlas Guadalajara | 10 | 5 | 3 | 2 | 22:14 | 8 | 18 |
| 4 |
|
UANL Tigres | 11 | 4 | 4 | 3 | 13:13 | 0 | 16 |
| 5 |
|
Club Tijuana | 10 | 4 | 1 | 5 | 9:15 | -6 | 13 |
| 6 |
|
CF Monterrey | 11 | 2 | 6 | 3 | 16:14 | 2 | 12 |
| 7 |
|
Club León | 10 | 3 | 2 | 5 | 11:16 | -5 | 11 |
| 8 |
|
Mazatlán FC | 11 | 2 | 3 | 6 | 13:25 | -12 | 9 |
| 9 |
|
Atlético San Luis | 11 | 1 | 3 | 7 | 9:19 | -10 | 6 |
| Play-offs | |
| Play-offs |
