| 1. Ronde | 12.01.2022 | Santos Laguna [U20] | - | UANL Tigres [U20] | 1:3 | ||||
| 2. Ronde | 16.01.2022 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 4:2 |  |
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| 3. Ronde | 23.01.2022 | Santos Laguna [U20] | - | Club Necaxa [U20] | 0:3 | ||||
| 4. Ronde | 06.02.2022 | Atlas Guadalajara [U20] | - | Santos Laguna [U20] | 0:1 | ||||
| 5. Ronde | 12.02.2022 | Santos Laguna [U20] | - | CF América [U20] | 0:0 |  |
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| 8. Ronde | 02.03.2022 | Santos Laguna [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 9. Ronde | 05.03.2022 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 10. Ronde | 12.03.2022 | Santos Laguna [U20] | - | Club Tijuana [U20] | 4:2 | ||||
| 11. Ronde | 18.03.2022 | Puebla FC [U20] | - | Santos Laguna [U20] | 0:1 | |
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| 13. Ronde | 26.03.2022 | CF Monterrey [U20] | - | Santos Laguna [U20] | 1:2 | ||||
| 14. Ronde | 16.04.2022 | Santos Laguna [U20] | - | Gallos Blancos [U20] | 2:2 | ||||
| 16. Ronde | 24.04.2022 | Santos Laguna [U20] | - | Club León [U20] | 0:3 | ||||
| 17. Ronde | 01.05.2022 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 2:2 |
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