| 2. Ronde | 15.01.2022 | CF Monterrey [U16] | - | Deportivo Guadalajara [U16] | 2:2 |  |
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| 3. Ronde | 22.01.2022 | Deportivo Guadalajara [U16] | - | Club León [U16] | 2:1 | ||||
| 5. Ronde | 05.02.2022 | Club Tijuana [U16] | - | Deportivo Guadalajara [U16] | 0:1 | ||||
| 8. Ronde | 26.02.2022 | UANL Tigres [U16] | - | Deportivo Guadalajara [U16] | 1:4 | ||||
| 10. Ronde | 12.03.2022 | Atlético San Luis [U16] | - | Deportivo Guadalajara [U16] | 0:1 | ||||
| 11. Ronde | 19.03.2022 | Deportivo Guadalajara [U16] | - | Club Tijuana [U16] | 2:0 | ||||
| 12. Ronde | 26.03.2022 | Club León [U16] | - | Deportivo Guadalajara [U16] | 0:3 | ||||
| 15. Ronde | 30.03.2022 | Deportivo Guadalajara [U16] | - | CF Monterrey [U16] | 5:1 | ||||
| 16. Ronde | 23.04.2022 | Atlas Guadalajara [U16] | - | Deportivo Guadalajara [U16] | 2:2 | ||||
| 18. Ronde | 07.05.2022 | Deportivo Guadalajara [U16] | - | UANL Tigres [U16] | 4:3 |
Mexico